Objective To explore the status and development trend of kinesiophobia after percutaneous coronary intervention（PCI） in patients with acute myocardial infarction（AMI）,and to provide evidence for the best intervention time point of kinesiophobia. Methods From November 2020 to June 2021,a total of 105 patients with AMI after PCI admitted to the Department of Cardiology of tertiary A general hospitals in Hangzhou were selected by convenience sampling method. The general data questionnaire,tampa scale of kinesiophobia-heart and cardiac anxiety questionnaire were used to investigate and observe the degree of kinetophobia and psychogenic anxiety at 3 time points（within 1 week of hospitalization,2 weeks after discharge and 3 months after discharge）. Results The kinesiophobia scores of AMI patients at 3 time points after PCI were（40.82±5.40）,（41.90±4.60）,（37.40±3.35）,which were higher than the norm（32.20±7.40）. The results of repeated measure ANOVA showed that different time,different age groups and cardiac anxiety significantly affected the score of kinesiophobia（P=0.022,P=0.048,P<0.001）. After the control for covariates,different time had a significant interaction with age（P=0.013）,T1 and T2 time had significant interaction with cardiac anxiety（P=0.001,P<0.001）. Conclusion Due to the interaction of time, age and cardiac anxiety, the level of kinetophobia in AMI patients was higher after PCI and within 3 months after discharge. At T2 time point, the score of kinesiophobia and cardiac anxiety in the young and middle-age groups was significantly higher than those in the elderly group. The trajectory of kinesiophobia showed a slight increase in acute convalescence period,and a natural trend of gradual decrease in middle and post convalescence period. The kineophobia kinesiophobia of AMI patients after PCI lasts for a long time with a wide impact,so it is necessary to timely carry out interventions.